SUBJECT How to classify hemolysis and non-hemolysis in the result of o.blood test strip?
DATE 2010.04.28 HIT 50662 FILE

Hemolysis and non-hemolysis can be recognized by the coloration on blood pad and each of them have different clinical meaning.

 

* In the case of Non-hemolysis : Hematuria (intact RBC) -> Indicated in dot form

* In the case of Hemolysis : Hemoglobinuria (lysed RBC) and Myoglobinuria -> solid color

 

Hematuria means that red blood cells are existed in the urine.  Hematuria can be generally caused by bleeding in the urinary system of human body. (by renal disease or dysfunction, infection, tumor or lesions, stone formation, generalized bleeding disorders, or anticoagulant usage)

 

Hemoglobinuria: Hemoglobin is separated from RBC in urine. It means that intact red blood cells is broken before the routine urinalysis strip test.

It may indicate

1.      significant intravascular hemolysis

2.      hemolysis within the kidney or the lower urinary tract

3.      hemolysis within the voided urine specimen itself by extra physical or chemical shock

myoglobinuria means the contain of myoglobin in urine. Myoglobin is released in urine after acute destruction of muscle fibers (rhabdomyolysis). It is rapidly cleared from the blood stream and excreted in urine as a red-brown pigment.

 

O.blood test strip can detect both hemoglobinuria and hematuria but hemoglobinuria cannot be detected by microscopic examination.

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